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Drs. Henry “Chip” Chambers and Warren Rose join Dr. Megan Klatt to tackle rifampin dosing for gram-positive infections. In this episode, they break down rifampin synergy studies and discuss what is the optimal dosing of rifampin for challenging gram-positive bacterial cases, in particular Staphylococcus aureus infections with or without retained hardware/devices. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/
References:
- Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis. Open Forum Infect Dis. 2022 Oct 31;9(11):ofac583. doi: 10.1093/ofid/ofac583. PMID: 36408468.
- Effectiveness of adjunctive rifampicin for treatment of Staphylococcus aureus bacteraemia: a systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2023 Oct 3;78(10):2419-2427. doi: 10.1093/jac/dkad214. PMID: 37583062.
- Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone? Open Forum Infect Dis. 2022 Oct 31;9(12):ofac582. doi: 10.1093/ofid/ofac582. PMID: 36504699.
Henry “Chip” Chambers, MD
Dr. Chambers is Professor of Medicine, Emeritus at UCSF. He has authored over 350 original publications, editorials, and textbook chapters in the areas of drug resistance, endocarditis, bacterial infections, and staphylococcal diseases. He has been a member of advisory groups for the CDC, a member of the IDSA treatment guidelines committee for skin and soft tissue infections, co-chaired the IDSA guidelines committee for treatment of methicillin-resistant Staphylococcus aureus infections, and co-chairs the IDSA guidelines committee for treatment of Staphylococcus aureus bacteremia.
Warren Rose, PharmD, MPH
Dr. Rose is an Associate Professor of Pharmacy and Medicine at the University of Wisconsin-Madison. His translational research on multi-drug-resistant pathogens, including Staphylococcus aureus has been continuously funded by the National Institute of Allergy and Infectious Diseases, professional societies/organizations, and the pharmaceutical industry.
