#107 – Dosing Consult: Valganciclovir

Drs. Anne-Grete Märtson, Megan Wimmer, and Evan Clemens join Dr. Erin McCreary to tackle the one of the hottest debates among providers taking care of immunocompromised patients, valganciclovir dosing! Learn all about the history of valganciclovir dosing, what is valganciclovir’s PK/PD target, and even valganciclovir therapeutic drug monitoring.
 
References:
  1. Märtson AG, Edwina AE, Kim HY, Knoester M, Touw DJ, Sturkenboom MGG, Alffenaar JC. Therapeutic Drug Monitoring of Ganciclovir: Where Are We? Ther Drug Monit. 2022 Feb 1;44(1):138-147. doi: 10.1097/FTD.0000000000000925. PMID: 34610621; PMCID: PMC8746890.
  2. Wiltshire H, Paya CV, Pescovitz MD, Humar A, Dominguez E, Washburn K, Blumberg E, Alexander B, Freeman R, Heaton N, Zuideveld KP; Valganciclovir Solid Organ Transplant Study Group. Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients. Transplantation. 2005 Jun 15;79(11):1477-83. doi: 10.1097/01.tp.0000164512.99703.ad. PMID: 15940035.

Anne Grete Märtson, PhD

Dr. Anne Grete Märtson, was a practicing clinical pharmacist and then got her PhD in the Netherlands. She is now an assistant professor at Leiden University in the Netherlands. She is the principal investigator of antiviral pharmacology for the Academic Center for Drug Research. Her research focuses on optimizing anti-infective therapy for immunocompromised patients through conducting clinical studies of therapeutic drug monitoring and modeling the pharmacokinetics and pharmacodynamics of different anti-infectives. She has published many papers in this space, including a 2021 publication in JAC about ganciclovir TDM and transplant recipients. And then another in 2022, which assesses the landscape of ganciclovir TDM currently.

Megan Wimmer, PharmD, BCIDP

Dr. Megan Wimmer is an infectious diseases pharmacist at the University of Wisconsin where they have an incredible pharmacist driven CMV monitoring clinic. Megan completed pharmacy residency in clinical pharmacology and Infectious diseases at the University of Wisconsin and also currently serves as the PGY2 Infectious Diseases Residency Program Director.

Even Clemens, PharmD, BCTXP

Dr. Evan Clemens is a clinical pharmacist specializing in solid organ transplant at the University of Washington. He completed a pharmacy residency in clinical pharmacology at the University of Washington and has been practicing as a solid organ transplant pharmacist since 2011 where he is a part of a multi-disciplinary team serving as an expert resource to help guide safe and effective use of complex drug regimens

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